The Metabolic Study

Currently Recruiting

17 Nov 2025 to 23 Dec 2025

$5,670

Metabolic dysfunction-associated steatohepatitis (MASH), previously known as non-alcoholic steatohepatitis (NASH), is a progressive liver condition linked to obesity, insulin resistance, and high cholesterol. It can lead to serious complications such as progressive liver disease and liver cancer.

Current treatment options are limited and often rely on lifestyle changes like diet and exercise. While some medications exist, they don’t work for everyone, highlighting the need for new therapies.

This clinical trial is evaluating a potential new injectable medication designed to activate two important pathways in the body that help regulate metabolism, reduce liver fat, and improve insulin sensitivity. These pathways are known to play a role in managing metabolic disorders and liver inflammation.

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Join our clinical trial

We are conducting this first-in-human (FIH) study to assess the safety, tolerability, and how the body processes the investigational treatment in healthy and overweight or obese adult volunteers. This is a vital early step before the treatment can be tested in patients with liver disease.

This FIH study has been carefully designed with strict safety protocols. Before participating, you will receive detailed information about the study, its procedures, and how risks are managed. You’ll also meet with one of our doctors to discuss any questions you may have.

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Why participate?

  • Help advance research into a potential new treatment for liver disease and metabolic disorders.
  • Be part of early-stage research that could benefit people with limited treatment options.
  • Contribute to the development of a therapy that targets a different pathway than existing medications.
  • Your involvement helps researchers gather essential data that could inform future therapies.

Trial details

Study duration

7 nights stay,
5 follow-up visits

Study medication

Administered via subcutaneous injection

Additional eligibility

  • Weight (Part 1 SAD): 51-129kg (inclusive)
  • Stable body weight <5kg change during
    the 90 days before Screening

Are you a match?

Age

18 - 55 years old

Remuneration

$5,670 *with screening reimbursement. Please see T&Cs.

Gender

Male or Female

BMI

BMI 22 - 35 kg/m2

Commitment

7 nights, 5 clinic visits

Medical condition

Not taking any medications

Register Your Interest

This form takes around 3–5 minutes to complete. Your information will remain confidential and is used only to assess your eligibility for current or future research studies.
Step 1 of 3
Contact Information




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Nucleus Network does not currently conduct clinical trials in your state. If you would like to receive study information should this situation change, please complete and submit this form.
Personal Information

This includes registering your interest with the Centre for Clinical Studies, Q-Pharm or Nucleus Network

Please call us on 1800 243 733 or schedule a call.


What is your date of birth?
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You need to be at least 18 years old to participate in clinical trials.


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Step 2 of 3
Medical History

We regularly have studies that allow participants who are (social) smokers.

We define an allergy as severe if symptoms include mouth/throat/face swelling, shortness of breath or a whole-body rash, or if it required hospitalisation

We regularly have studies that allow for/require participants with asthma.



We regularly have studies that allow for/require participants with medical conditions.

Medications & Contraception Requirements

We regularly have studies that allow participants with depression that is well-managed on a stable dose of medication.

If the only prescription medication you currently use is hormonal contraception and/or Ventolin, please select No above. We regularly have studies that allow for participants who take a stable dose of prescription medication.


  • Abstinence from sex with anyone of the opposite sex for at least 2 months
  • Using a condom + your female sexual partner(s) using a separate form of birth control
  • You or your sexual partner(s) had a vasectomy/hysterectomy
  • Your sexual partner(s) are post-menopausal


Only you taking birth control or your partner(s) using a condom is not an acceptable option, but using both together is. The morning after pill is not an acceptable form of birth control.

  • Abstinence, by choice, from sex with anyone of the opposite sex for the last 2 months + remaining abstinent for at least 2 months after study participation
  • You using birth control + your male sexual partner(s) using a condom
  • You or your sexual partner(s) had a hysterectomy/vasectomy
  • You are post-menopausal



Step 3 of 3
Study Preferences

While longer studies generally have a higher reimbursement, there are also studies with multiple short stays that have high reimbursements.
Referral Information



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