Chronic Spontaneous Urticaria (CSU) is a skin condition that causes frequent hives and intense itching, often without a known cause. It affects around 65 million people globally, is more common in women, and can significantly impact quality of life—often leading to anxiety or depression due to the constant discomfort.
Most people with CSU start treatment with antihistamines, but about 1 in 3 patients don’t get enough relief. For those who don’t respond, doctors may try injectable medications which are often inconvenient for patients, and help some, but not all patients.
This clinical trial is testing a potential new oral medication, which is designed to block a specific “itch switch” in the body. This switch is found on immune cells and nerves in the skin and is believed to play a key role in triggering hives and inflammation.
Requirements
- Male or Female
- Healthy
- 18 - 60 years old
- BMI 18 - 32 kg/m2
- Not taking any medications
- Non-smoker or Occasional smoker
Start dates
10 Nov 2025 to 16 Dec 2025
Study visits
10 nights, 1 clinic visit