26-005 - Healthy Volunteer Study
Currently Recruiting
25 Jan 2027
£4,040
London, United Kingdom
A trial in healthy participants investigating an experimental new medicine for treating Von Willebrand disease (VWD).
Join our clinical trial
We’re doing this trial to test an experimental new medicine for VWD. We need to test the trial medicine in healthy people before it’s tested in patients.
We’re doing this trial to assess the potential side effects of a single dose of the trial medicine when given as an injection under the skin. We’ll also investigate how much of the trial medicine (and its breakdown products) enters the blood and urine, how long it takes the body to remove it, and whether it has any effects on proteins in the body that are involved in blood clotting.
Why participate?
If you take part in this trial, you’ll be helping medical research – you could help us develop a potential new treatment for VWD.
VWD is the most common inherited bleeding disorder, meaning a person is born with a condition that affects how their blood clots. Symptoms can vary, but people with VWD may bleed for longer than normal, bruise easily, bleed more than expected after an injury or surgery, develop bleeding in their joints, or experience heavy menstrual periods.
The trial medicine is a type of medicine known as an ‘siRNA’ (small interfering RNA), which works by temporarily reducing the activity of specific biological signals inside the body. We hope it may help reduce the bleeding symptoms experienced by people with VWD.
Trial details
Delivery method
You’ll receive the trial medicine by injection under the skin of your abdomen.
Schedule
During the 4 weeks before you start the trial, we’ll screen you to see if you’re suitable.
You’ll stay on the ward for 4 days and 3 nights in a row.
You’ll then return to the ward 7 times for outpatient visits. The last visit will be about 16 weeks (4 months) after your dose of trial medicine
The planned admission dates are:
- 25 January 2027
- 10 February 2027
Inclusion criteria:
You must:
- be a healthy man or woman, aged 18 to 45
- have a BMI between 18 and 30
- be registered with a GP
- be willing to use contraception- we’ll tell you what’s acceptable.
Exclusion criteria
You must not:
- smoke, vape or use any nicotine products, or have done so in the last 3 months
- use regular medication (certain hormonal contraceptives are allowed)
- have received an siRNA medicine in the 6 months before admission
- have a history of blood clots or a family history of coagulation disorders
- have travelled on a long-haul journey (4 hours or more) within 8 weeks before receiving the trial medicine, or plan any long-haul travel for approximately 4 months afterwards
Are you a match?
Age
18 - 45 years old
Study payment
£4,040
Gender
Male or Female
BMI
BMI 18 - 30 kg/m2
Commitment
3 nights, 7 outpatient visits