The Strive Study

Currently Recruiting

$6,337

Minneapolis, United States

At Nucleus Network, we lead the way in advancing medical research through clinical trials that explore new investigational medicines aimed at improving lives across a wide range of health conditions. 

We’re currently inviting healthy volunteers to take part in a clinical study evaluating a potential new treatment for cystic fibrosis.  

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Join our clinical trial

The study will look at how study drug SION-451 interacts with midazolam, a commonly used medication. Midazolam is not being used for anxiety or sedation in this study, but rather to help determine whether SION-451 affects how similar drugs are processed in the body. 

  • Twice daily dosing
  • SION-451 co-administered with midazolam
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Trial details

Purpose:

This study is a drug-drug interaction (DDI) study, which means it evaluates the effect that one drug has on the breakdown of another drug. This study will investigate whether there is the potential for a drug-drug interaction between study drug SION-451 and midazolam commonly used for anxiety or sedation. 

Commitment

  • 1 Inpatient Stay 12 nights/ 13 days
    • Admit 2/16/26-2/28/26
    • End of study phone call 3/6/26

Meal Requirements

Foods to avoid: Avoid cruciferous vegetables, charcoal-grilled meats, and poppy seeds for 48 hours before Day 1 through the entire trial

Are you a match?

Age

18 - 55 years old

Remuneration

$6,337 *with screening reimbursement. Please see T&Cs.

Gender

Male or Female

BMI

BMI 18 - 32 kg/m2

Commitment

12 nights

Join our Vital Research: Participate in a Clinical Trial at Nucleus Network

We’re looking for healthy people to participate in clinical studies of new medications. All visits occur at Nucleus Network’s specialized clinic located in the heart of the Minneapolis-St. Paul metropolitan area. We currently only allow participants who live within 300 miles of our clinic. 

  • You'll be fully informed about all aspects of the trial before consenting to participate
  • You'll receive $400 to $600 per day in consideration of your time and effort
  • You'll have complimentary access to high-speed internet, enabling you to work, study or stay connected
  • You'll have access to a recreational room to keep you entertained and occupied in your free time 

Join a clinical trial and help researchers investigate new potential treatments for a wide range of medical conditions. Your participation can help shape the future of medicine.


Answer a few questions to see if you might be eligible:


Step 1 of 3

Contact information




Please make sure there is no space at the end of your email address, as this will lead to an error message.

Please start your phone number with 1, using only numbers
The phone number you have entered does not appear to be a valid US phone number. Please check your details and enter a valid phone number starting with country code 1.

By checking Yes - you will receive marketing text messages regarding upcoming studies at NN.

We sometimes have studies without overnight stays. Please complete the form even if you can't stay overnight.

This includes registering your interest with Prism Research or Nucleus Network

Please call us on 612-315-6490 or schedule a call.

If you currently reside in Australia, please complete this AUSTRALIA FORM.

STEP 2 OF 3

Personal information


This refers to the sex that you were assigned at birth, not your gender identity.

We regularly have studies that allow participants who are (social) smokers.


Please only select 'Yes' if you have used recreational drugs in the last month. Some studies allow positive THC tests, as long as participants agree to abstain during the entire study.

What is your date of birth?

Month Day Year

You need to be at least 18 years old to participate in clinical trials.





lbs



Step 3 of 3

Medical history





  • Using a condom + your female partner(s) using a separate form of birth control.
  • You or your partner(s) had a vasectomy/hysterectomy
  • Your partner(s) are post-menopausal
  • Abstinence from heterosexual sex for at least 1 month prior to screen and throughout study


  • You using birth control + your male partner(s) using a condom
  • You or your partner(s) had a hysterectomy/vasectomy
  • You are post-menopausal
  • Abstinence from heterosexual sex for at least 1 month prior to screen and throughout study



We define an allergy as severe if symptoms include mouth/throat/face swelling, shortness of breath or a whole-body rash.




We regularly have studies that allow for/require participants with medical conditions.




Please leave blank if you don't have the lab value.


This includes one or multiple instance.

Medical records (e.g., medical chart notes, hospital discharge summaries, radiology/pathology reports)

Medical records are REQUIRED (can be paper copy, mychart, email/faxed to clinic)

Urine collection takes place at our clinic during the inpatient stay periods.

Specifically a low oxalate diet (high protein/ low carb).


If the prescription medication you currently use is prescription vitamins and/or hormonal contraception, please select No above. We sometimes have studies that allow for participants who take a stable dose of prescription medication.




Mailing Address




5 numbers only


By completing this form you express your interest in participating in a clinical trial of new medication.


Before your potential participation you will speak with our Recruitment and Medical teams who will answer all of your questions.

By registering your interest, you are consenting to receive communications about studies that could be a good fit for you. You can unsubscribe at any time. View our privacy policy for more information.