The Strive Study

Closing Soon

18 May to 30 May 2026

$6,337

Minneapolis, United States

At Nucleus Network, we lead the way in advancing medical research through clinical trials that explore new investigational medicines aimed at improving lives across a wide range of health conditions. 

We’re currently inviting healthy volunteers to take part in a clinical study evaluating a potential new treatment for cystic fibrosis.  

We are currenlty recruiting the 2nd group for this study.

Apply now Speak with us 612-315-6490

Join our clinical trial

The study will look at how study drug SION-451 interacts with midazolam, a commonly used medication. Midazolam is not being used for anxiety or sedation in this study, but rather to help determine whether SION-451 affects how similar drugs are processed in the body. 

  • Twice daily dosing
  • SION-451 co-administered with midazolam
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Trial details

Purpose:

This study is a drug-drug interaction (DDI) study, which means it evaluates the effect that one drug has on the breakdown of another drug. This study will investigate whether there is the potential for a drug-drug interaction between study drug SION-451 and midazolam commonly used for anxiety or sedation. 

Commitment

  • 1 Inpatient Stay 12 nights/ 13 days
    • Admit 5/18/26-5/30/26
    • End of study phone call 6/5/2026

Meal Requirements

Foods to avoid: Avoid cruciferous vegetables, charcoal-grilled meats, and poppy seeds for 48 hours before Day 1 through the entire trial

Schedule a call

Schedule a call

Are you a match?

Age

18 - 55 years old

Remuneration

$6,337 *with screening reimbursement.
Full details outlined in consent form.

Gender

Male or Female

BMI

BMI 18 - 32 kg/m2

Commitment

12 nights

Join our Vital Research: Participate in a Clinical Trial at Nucleus Network

All modern medications we have today are available thanks to thousands of people who contributed through clinical trials. Your decision to take part is personal. By choosing to participate, you're contributing to advancements in healthcare and improved quality of life for multitudes of people with health challenges.

  • You'll be fully informed about all aspects of the trial before consenting to participate
  • You'll have access to a recreational room to keep you entertained and occupied in your free time
  • You'll receive $400 to $600 per day in consideration of your time and effort
  • You'll have complimentary access to high-speed internet, enabling you to work, study or stay connected

All visits occur at Nucleus Network’s specialized clinic located in the heart of the Minneapolis-St. Paul metropolitan area.  


Answer a few questions to see if you might be eligible:

Step 1 of 3

Contact information




If you don't have a middle name please leave blank.

Please make sure there is no space at the end of your email address, as this will lead to an error message.

Please start your number with 1, and only use numbers.
The phone number you have entered does not appear to be a valid US phone number. Please check your details and enter a valid phone number starting with country code 1.

By checking Yes - you will receive marketing text messages regarding upcoming studies at NN.

We occasionally have studies without inpatient stays. Please complete the form even if you can't stay overnight.
STEP 2 OF 3

Personal information


This refers to the sex that you were assigned at birth, not your gender identity.

We regularly have studies that allow participants who are social smokers.


Please only select 'Yes' if you have used recreational drugs in the last month. Some studies allow positive THC tests, as long as participants agree to abstain during the entire study.

What is your date of birth?

Month Day Year

You need to be at least 18 years old to participate in clinical trials.





lbs



Step 3 of 3

Medical history




  • Using a condom + your female partner(s) using a separate form of birth control.
  • You or your partner(s) had a vasectomy/hysterectomy
  • Your partner(s) are post-menopausal
  • Abstinence from heterosexual sex for at least 1 month prior to screen and throughout study


  • You using birth control + your male partner(s) using a condom
  • You or your partner(s) had a hysterectomy/vasectomy
  • You are post-menopausal
  • Abstinence from heterosexual sex for at least 1 month prior to screen and throughout study



At least 12 months without menses or bilateral oophorectomy

We define an allergy as severe if symptoms include mouth/throat/face swelling, shortness of breath or a whole-body rash.


We regularly have studies that allow participants with asthma.


We regularly have studies that allow for participants with certain medical conditions.




Please leave blank if you don't have the lab value.



If the prescription medication you currently use is prescription vitamins and/or hormonal contraception (the pill, IUD, contraceptive implant, etc) please select No above.





If you select 'Yes' we will ask for your mailing address. None of the data collected from you will be disclosed to other organizations without your prior agreement.




5 numbers only


By completing this form you express your interest in participating in a clinical trial of new medication.


Before your potential participation you will speak with our Recruitment and Medical teams who will answer all of your questions.

By registering your interest, you are consenting to receive communications about studies that could be a good fit for you. You can unsubscribe at any time. View our privacy policy for more information.