The Progressive Immunity Study

Currently Recruiting

29 Dec 2025 to 23 Feb 2026

Up to $11,930

Brisbane, Australia

We are conducting a clinical trial to evaluate a potential new treatment for immune-mediated diseases in healthy participants. This study aims to assess the safety, tolerability, and how the body absorbs and processes the potential new treatment. 

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Join our clinical trial

The investigational treatment is being developed to potentially help manage immune-mediated diseases by inhibiting a specific enzyme, which reduces the activity of certain immune cells. This study builds on previous data and aims to explore higher doses and the effect of food on the treatment’s absorption to optimize its safety and effectiveness. 

This study is divided into three parts, each focusing on different aspects of the treatment. While all clinical trials have risks, this trial has been carefully designed to minimize risks for participants. Before joining, you will receive detailed information about the trial, its risks, and our strategies to mitigate them. You will also have an appointment with one of our doctors, who will be happy to answer any questions you may have. 

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Why participate?

  • Contribute to scientific research that may support the development of future treatment options. 
  • Help researchers understand how the investigational treatment is absorbed and processed in the body under different conditions.  

Your Role 

As a participant, you’ll receive the study medication and undergo assessments to monitor how your body responds. Your involvement will provide essential data that can help guide future research. 

Trial details

Study medication

Administered via oral tablet.

Ethics

An independent ethics committee has approved this clinical trial. 

Additional eligibility

  • Body weight: ≥50 kg  
  • Healthy: Based on medical history, physical exam, lab results, ECG, and vital signs 
  • Non-smoker: No use of nicotine products, including vaping, within 1 month prior to screening 
  • Not taking any prescription medication: Except for contraception 
  • Willingness to abstain from alcohol, grapefruit, and certain medications 

Study duration

21-night inpatient stay, 4 follow-up visits, and 1 phone call.

Are you a match?

Age

18 - 60 years old

Remuneration

Up to $11,930 *with screening reimbursement. Please see T&Cs.

Gender

Male or Female (Post-menopausal)

BMI

BMI 18 - 32 kg/m2

Commitment

21 nights, 4 clinic visits

Register Your Interest

This form takes around 3–5 minutes to complete. Your information will remain confidential and is used only to assess your eligibility for current or future research studies.
Step 1 of 3
Contact Information




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Nucleus Network does not currently conduct clinical trials in your state. If you would like to receive study information should this situation change, please complete and submit this form.
Personal Information

This includes registering your interest with the Centre for Clinical Studies, Q-Pharm or Nucleus Network

Please call us on 1800 243 733 or schedule a call.


What is your date of birth?
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You need to be at least 18 years old to participate in clinical trials.


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Step 2 of 3
Medical History

We regularly have studies that allow participants who are (social) smokers.

We define an allergy as severe if symptoms include mouth/throat/face swelling, shortness of breath or a whole-body rash, or if it required hospitalisation

We regularly have studies that allow for/require participants with asthma.



We regularly have studies that allow for/require participants with medical conditions.

Medications & Contraception Requirements

We regularly have studies that allow participants with depression that is well-managed on a stable dose of medication.

If the only prescription medication you currently use is hormonal contraception and/or Ventolin, please select No above. We regularly have studies that allow for participants who take a stable dose of prescription medication.


  • Abstinence from sex with anyone of the opposite sex for at least 2 months
  • Using a condom + your female sexual partner(s) using a separate form of birth control
  • You or your sexual partner(s) had a vasectomy/hysterectomy
  • Your sexual partner(s) are post-menopausal


Only you taking birth control or your partner(s) using a condom is not an acceptable option, but using both together is. The morning after pill is not an acceptable form of birth control.

  • Abstinence, by choice, from sex with anyone of the opposite sex for the last 2 months + remaining abstinent for at least 2 months after study participation
  • You using birth control + your male sexual partner(s) using a condom
  • You or your sexual partner(s) had a hysterectomy/vasectomy
  • You are post-menopausal



Step 3 of 3
Study Preferences

While longer studies generally have a higher reimbursement, there are also studies with multiple short stays that have high reimbursements.
Referral Information



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