The Insight Study

Currently Recruiting

16 Nov 2025 to 1 Dec 2025

Up to $7,700

This clinical trial is testing a potential new oral medication, which is designed to block a specific “itch switch” in the body. This switch is found on immune cells and nerves in the skin and is believed to play a key role in triggering hives and inflammation. 

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Join our clinical trial

This clinical trial is testing a potential new oral medication, which is designed to block a specific “itch switch” in the body. This switch is found on immune cells and nerves in the skin and is believed to play a key role in triggering hives and inflammation. 

Chronic Spontaneous Urticaria (CSU) is a skin condition that causes frequent hives and intense itching, often without a known cause. It affects around 65 million people globally, is more common in women, and can significantly impact quality of life—often leading to anxiety or depression due to the constant discomfort.

Most people with CSU start treatment with antihistamines, but about 1 in 3 patients don’t get enough relief. For those who don’t respond, doctors may try injectable medications which are often inconvenient for patients, and help some, but not all patients.  

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Why participate?

We are conducting this first-in-human (FIH) study to assess the safety, tolerability, and how the body processes the investigational treatment in healthy adult volunteers. This is an important early step in understanding how the therapy behaves in the body before it can be tested in patient populations. 

  • Help advance research into a potential new treatment for chronic hives. 
  • Be part of early-stage research that could benefit people who don’t respond well to current allergy medications. 
  • Contribute to the development of a potential new medicine that targets a different pathway than traditional antihistamines. 
  • Your involvement helps researchers gather essential data that could inform the next generation of CSU therapies.  

Are you a match?

Age

18 - 60 years old

Remuneration

Up to $7,700 *with screening reimbursement. Please see T&Cs.

Gender

Male or Female

BMI

BMI 19 - 32 kg/m2

Commitment

15 nights, 1 clinic visit

Register Your Interest

This form takes around 3–5 minutes to complete. Your information will remain confidential and is used only to assess your eligibility for current or future research studies.
Step 1 of 3
Contact Information




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Nucleus Network does not currently conduct clinical trials in your state. If you would like to receive study information should this situation change, please complete and submit this form.
Personal Information

This includes registering your interest with the Centre for Clinical Studies, Q-Pharm or Nucleus Network

Please call us on 1800 243 733 or schedule a call.


What is your date of birth?
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You need to be at least 18 years old to participate in clinical trials.


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Step 2 of 3
Medical History

We regularly have studies that allow participants who are (social) smokers.

We define an allergy as severe if symptoms include mouth/throat/face swelling, shortness of breath or a whole-body rash, or if it required hospitalisation

We regularly have studies that allow for/require participants with asthma.



We regularly have studies that allow for/require participants with medical conditions.

Medications & Contraception Requirements

We regularly have studies that allow participants with depression that is well-managed on a stable dose of medication.

If the only prescription medication you currently use is hormonal contraception and/or Ventolin, please select No above. We regularly have studies that allow for participants who take a stable dose of prescription medication.


  • Abstinence from sex with anyone of the opposite sex for at least 2 months
  • Using a condom + your female sexual partner(s) using a separate form of birth control
  • You or your sexual partner(s) had a vasectomy/hysterectomy
  • Your sexual partner(s) are post-menopausal


Only you taking birth control or your partner(s) using a condom is not an acceptable option, but using both together is. The morning after pill is not an acceptable form of birth control.

  • Abstinence, by choice, from sex with anyone of the opposite sex for the last 2 months + remaining abstinent for at least 2 months after study participation
  • You using birth control + your male sexual partner(s) using a condom
  • You or your sexual partner(s) had a hysterectomy/vasectomy
  • You are post-menopausal



Step 3 of 3
Study Preferences

While longer studies generally have a higher reimbursement, there are also studies with multiple short stays that have high reimbursements.
Referral Information



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