Early-Phase clinical expertise

Accelerating your development with clinics located within major medical precincts, fast start-up, and specialist recruitment across Australia, the US and the UK.

Nucleus Network is the only dedicated early-phase clinical trial facility with operations in Australia, the United States and the United Kingdom. For over 30 years, we’ve delivered high-quality clinical pharmacology studies with the speed, safety, and scale sponsors need to stay competitive.

With harmonized operations across Melbourne, Brisbane, Minneapolis, and London, we support First-in-Human (FIH) through complex patient cohort studies across various therapeutic areas.

What sets us apart.

Speed

Ethics approvals in 1–2 weeks and first participant dosing in as little as 4–6 weeks*.

Safety

All clinics are located within major medical precincts with 24/7 medical oversight and global regulatory compliance (FDA, EMA, TGA).

Recruitment

Extensive healthy and patient databases, including renal, hepatic, and elderly populations. Fully in-house marketing and call centre support.

Experience

2,500+ early-phase trials completed. 30+ years of experience. 250+ sponsor audits, including FDA and EMA inspections.

Early phase.
Fully delivered.

From first-in-human to proof of concept, we specialize in the clinical pharmacology studies that shape regulatory pathways and bring new therapies to life. With deep expertise, purpose-built facilities, and a globally connected team, we deliver reliable data across a broad range of study types:

  • First-in-Human (FIH)
  • Biologics and Biosimilars
  • Drug–Drug Interaction (DDI)
  • Bioavailability & Bioequivalence (BA/BE)
  • Renal and Hepatic Impairment
  • Vaccines
  • Special Populations
  • Proof of Concept (POC)

Therapeutic areas we support.

Our specialist facilities, experienced investigators, and procedural capabilities enable us to execute trials across a wide range of therapeutic areas, including high-intensity and biomarker-driven designs.

Cardiology

  • TTE
  • Telemetry
  • Holter monitoring

Dermatology

  • Punch Biopsies
  • Skin irritation assessment
  • PASI scoring

Gastroenterology

  • Fibro scan
  • Sigmoidoscopy
  • Liver ultrasound/li>

Immunology

  • Gluten challenge
  • Nasal challenge
  • Skin prick allergy test

Infectious Diseases

  • Group A Streptococcus challenge model
  • Malaria challenge model

Metabolism & Endocrinology

  • Metabolic Calorimeter
  • DEXA imaging
  • Glucose clamping
  • Glucose tolerance test
  • Mixed meal tolerance test
  • MRI PDFF

Neurology

  • Lumbar puncture
  • EEG
  • Cogstate battery
  • Pain & Thermostimulatory

Ophthalmology

  • Tonometry
  • Dark adaptometry
  • BCVA-ETDRS
  • FAF
  • Biomicroscopy
  • Fundus Exam
  • OCT & ERG

Radiology

  • Onsite CT imaging
  • Onsite PET imaging
  • Onsite X-Ray
  • Onsite Ultrasound
  • Onsite MRI

Respiratory

  • Bronchoalveolar lavage (BAL)
  • Spirometry (FEV1, FVC)
  • NO2 assay

Women’s Health

  • Colposcopy
  • PAP Smears

Integrated, global operations

With unified oversight across Australia, the U.S. and the UK, sponsors benefit from:

  • Consistent quality and data integrity
  • Parallel site activations
  • Flexibility in global program design

We’re strategically positioned in clinical research hubs, with co-located hospital access and proximity to diverse participant populations.

Learn more about our global advantage

Start your trial with confidence

From protocol feasibility to first dose, our team delivers clinical trial execution you can rely on. Backed by hospital-grade safety, rapid timelines, and 30+ years of proven experience.

Partner with us

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