The Liver Research Study

Currently Recruiting

10 May to 24 May 2026

Up to $4,370

Melbourne, Australia

The study drug is being developed for rare genetic liver diseases. These diseases happen because of a mistake in the DNA called a “nonsense mutation.” This mistake acts like a stop sign in the middle of an important gene, so the body can’t make the full protein it needs. Without these proteins, the body’s metabolism doesn’t work properly, leading to serious conditions like phenylketonuria (PKU), organic acidemias, and urea cycle disorders. 

The study drug works by sending a special molecule into the liver using tiny fat-based particles. This molecule helps the body “read through” the stop signs in the gene, so it can finish making the protein correctly. In other words, it fixes the root cause of the problem instead of just treating symptoms. 

Right now, there are no approved treatments that repair these mutations. Current options like strict diets or liver transplants only manage symptoms and can be very hard on patients. The study drug would be the first treatment designed to actually correct the genetic error, giving the body the ability to make the missing protein and potentially change the course of these diseases. Making this study an important trial to move medicine forward.

Apply now Speak with us 1300 569 066

Join our clinical trial

This is a first-in-human (FIH) study, meaning it is the first time the potential treatment is being tested in people. The study has been carefully designed with strict safety protocols and has been approved by an independent ethics committee. It is not known whether the study drug may cause unexpected, serious, or life-threatening side effects. While these are considered unlikely, you will be carefully monitored throughout the study and provided with prompt treatment if any such effects occur.

Before joining, you’ll receive detailed information about the study, meet with a doctor, and have the chance to ask any questions.

What to expect

  • Participation in a monitored clinical environment
  • Study visits scheduled
  • Support from a professional medical team
  • Reimbursement for your time and commitment

Trial details

Study duration

  • 7 nights stay
  • 1 follow-up visit

Study medication

Administered as an intravenous (IV) infusion

Additional eligibility

• Non-smokers or if current smoker must be willing to refrain from smoking during the
inpatient stay.

Ethics

This study has been reviewed and approved by an independent ethics committee.

Are you a match?

Age

18 - 65 years old

Remuneration

Up to $4,370 *with screening reimbursement. Please see T&Cs.

Gender

Male or Female

BMI

BMI 18 - 35 kg/m2

Commitment

7 nights, 1 clinic visit

Medical condition

Not taking any medications

Register your interest

This form takes around 3–5 minutes to complete. Your information will remain confidential and is used only to assess your eligibility for current or future research studies.
Step 1 of 3
Contact Information




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Nucleus Network does not currently conduct clinical trials in your state. If you would like to receive study information should this situation change, please complete and submit this form.
Personal Information

This includes registering your interest with the Centre for Clinical Studies, Q-Pharm or Nucleus Network

Please call us on 1800 243 733


What is your date of birth?
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You need to be at least 18 years old to participate in clinical trials.


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Step 2 of 3
Medical History

We regularly have studies that allow participants who are (social) smokers.

We define an allergy as severe if symptoms include mouth/throat/face swelling, shortness of breath or a whole-body rash, or if it required hospitalisation

We regularly have studies that allow for/require participants with asthma.



We regularly have studies that allow for/require participants with medical conditions.

Medications & Contraception Requirements

We regularly have studies that allow participants with depression that is well-managed on a stable dose of medication.

If the only prescription medication you currently use is hormonal contraception and/or Ventolin, please select No above. We regularly have studies that allow for participants who take a stable dose of prescription medication.


  • Abstinence from sex with anyone of the opposite sex for at least 2 months
  • Using a condom + your female sexual partner(s) using a separate form of birth control
  • You or your sexual partner(s) had a vasectomy/hysterectomy
  • Your sexual partner(s) are post-menopausal


Only you taking birth control or your partner(s) using a condom is not an acceptable option, but using both together is. The morning after pill is not an acceptable form of birth control.

  • Abstinence, by choice, from sex with anyone of the opposite sex for the last 2 months + remaining abstinent for at least 2 months after study participation
  • You using birth control + your male sexual partner(s) using a condom
  • You or your sexual partner(s) had a hysterectomy/vasectomy
  • You are post-menopausal



Step 3 of 3
Study Preferences

While longer studies generally have a higher reimbursement, there are also studies with multiple short stays that have high reimbursements.
Referral Information



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