The Enzyme Food Study

Currently Recruiting

8 Apr to 28 Apr 2026

Up to $8,460

Melbourne, Australia

We are conducting a clinical trial to evaluate a new investigational treatment, in healthy participants. This study aims to assess the safety, tolerability, and how the body processes the medication under different conditions, including variations in food intake.

The investigational treatment is being developed as a potential future treatment for phenylketonuria (PKU), a genetic disorder that leads to the accumulation of phenylalanine (Phe) in the body. Phenylalanine is an amino acid found in many foods and is important for normal growth and development, but too much of it can be harmful for people with PKU.

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Join our clinical trial

This is a Phase 1, first-in-human (FIH) study, meaning it is the first time this investigational treatment is being evaluated in humans. This clinical trial has been carefully designed to minimize risks for participants. Prior to participation, you will be provided with detailed information about the trial, its risks, and our mitigation strategies. You will also have an appointment with one of our doctors, who will be happy to answer any questions you may have.

Why participate?

  • Contribute to scientific research that may support the development of future treatment options for PKU.
  • Help researchers understand how the investigational drug is absorbed and processed in the body.
  • Play a key role in determining how factors like food intake may influence the drug’s effect

Trial details

Study medication

Administered via oral tablet and mini tablet.

Study duration

  • 17 nights stay
  • 1 follow-up visit

Additional Eligibility

  • Weight over 40 kg
  • Non-smokers for at least 2 weeks prior to dosing

Ethics

An independent ethics committee has approved this clinical trial

Are you a match?

Age

18 - 55 years old

Remuneration

Up to $8,460 *with screening reimbursement. Please see T&Cs.

Gender

Male or Female

BMI

BMI 18 - 40 kg/m2

Commitment

17 nights, 1 clinic visit

Register Your Interest

This form takes around 3–5 minutes to complete. Your information will remain confidential and is used only to assess your eligibility for current or future research studies.
Step 1 of 3
Contact Information




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Nucleus Network does not currently conduct clinical trials in your state. If you would like to receive study information should this situation change, please complete and submit this form.
Personal Information

This includes registering your interest with the Centre for Clinical Studies, Q-Pharm or Nucleus Network

Please call us on 1800 243 733


What is your date of birth?
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You need to be at least 18 years old to participate in clinical trials.


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Step 2 of 3
Medical History

We regularly have studies that allow participants who are (social) smokers.

We define an allergy as severe if symptoms include mouth/throat/face swelling, shortness of breath or a whole-body rash, or if it required hospitalisation

We regularly have studies that allow for/require participants with asthma.



We regularly have studies that allow for/require participants with medical conditions.

Medications & Contraception Requirements

We regularly have studies that allow participants with depression that is well-managed on a stable dose of medication.

If the only prescription medication you currently use is hormonal contraception and/or Ventolin, please select No above. We regularly have studies that allow for participants who take a stable dose of prescription medication.


  • Abstinence from sex with anyone of the opposite sex for at least 2 months
  • Using a condom + your female sexual partner(s) using a separate form of birth control
  • You or your sexual partner(s) had a vasectomy/hysterectomy
  • Your sexual partner(s) are post-menopausal


Only you taking birth control or your partner(s) using a condom is not an acceptable option, but using both together is. The morning after pill is not an acceptable form of birth control.

  • Abstinence, by choice, from sex with anyone of the opposite sex for the last 2 months + remaining abstinent for at least 2 months after study participation
  • You using birth control + your male sexual partner(s) using a condom
  • You or your sexual partner(s) had a hysterectomy/vasectomy
  • You are post-menopausal



Step 3 of 3
Study Preferences

While longer studies generally have a higher reimbursement, there are also studies with multiple short stays that have high reimbursements.
Referral Information



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