Coronaviruses, so named for their “crown-like” appearance, are a large family of viruses that spread from animals to humans and include diseases such as Middle East Respiratory Syndrome (MERS) and SARS
A new strain of coronavirus, SARS-CoV-2, first appeared in late 2019 in China before beginning its rapid spread across the globe. This was later called COVID-19.
The disease causes severe pneumonia-like symptoms in many of those infected.
While much remains unknown about the new coronavirus, it is known that the virus can spread via human-to-human transmission before any symptoms appear.
Nucleus Network provides high-quality, first-in-human and early-phase trials for biotechnology and pharmaceutical companies across the USA, Europe, and Asia. Located within cutting-edge health precincts, Nucleus Network’s cost-effective, accelerated clinical development solutions are supported by advanced technology, clinical excellence, and research expertise.
Nucleus Network is advancing medicine, improving lives.
2003: Nucleus Network established by the Baker ID Heart and Diabetes Institute
On an annual basis, Nucleus Network conducts approx. 60 Phase 1 studies in healthy volunteers and patient populations. We regularly conduct vaccine clinical trials.
Nucleus Network is Australia’s largest Phase 1 clinical trials provider
Nucleus Network owns 150 beds of the total approximate 250 dedicated Phase 1 beds available in Australia
We are the only Phase 1 provider in Australia with more than one site (Melbourne and Brisbane)
We have a database of potential participants of over 100,000 across our three sites.
Strong interest in participating in COVID-19 vaccine studies:
Dr Jason Lickliter As Chief Medical Officer, Dr Jason Lickliter heads Nucleus Network’s Medical Department and a multi-site team of Medical Officers. Jason has extensive experience across all aspects of early phase clinical trials from protocol design and implementation to the integration of Biomarker studies and advanced imaging into clinical research.
With a Medical Oncology and Clinical Hematology background, his achievements include the establishment of a Phase I Cancer Trials Program at Monash Medical Centre.
Dr Paul Griffin Dr Paul Griffin is an Infectious Diseases Physician and Microbiologist at Nucleus Network’s Brisbane site; where he has overseen more than 100 clinical trials, predominantly in Infectious Diseases. He is the Director of Infectious Diseases at Mater Health Services in Brisbane and Conjoint Associate Professor at the University of Queensland School of Medicine and Affiliate Associate Professor Mater Research Institute.
He has fellowships in Infectious Diseases from the Royal Australasian College of Physicians, in Clinical Microbiology from the Royal College of Pathologists of Australasia and from the Australasian College of Tropical Medicine.
What is a Clinical Trial? The World Health Organization (WHO) definition for a clinical trial is ‘any research study that prospectively assigns human participants or groups of humans to one or more health-related interventions to evaluate the effects on health outcomes’.
Clinical trials are designed under Good Clinical Practice principles and are designed, reviewed and approved before they even start. Clinical trials can use healthy volunteers, or be patient based.
Phases of Clinical Trials:
Phase 1: Safety and tolerance Phase 1 studies usually test new drugs for the first time in a small group of people to evaluate a safe dosage range and identify side effects.
Phase 2: Efficacy and safety Phase 2 studies test treatments that have been found to be safe in Phase 1 but now need a larger group of human subjects to monitor for any adverse effects.
Phase 3: Safety, efficacy or effectiveness Phase 3 studies are conducted on larger populations and in different regions and countries and are often the step right before a new treatment is approved.
Phase 4: Post-marketing surveillance or resolution of treatment uncertainties Phase 4 studies take place after country approval and there is a need for further testing in a wide population over a longer timeframe.
BIOTECH IN AUSTRALIA:
Australia is an emerging world-leader in health precincts and bio-tech clusters and is renowned globally for the quality of its medical research.
According to AusBiotech, clinical trials in Australia contribute around $1billion annually to our economy, drawing around $650m of foreign investment from approx. 1000 clinical trials.